A pan-cancer compendium of chromosomal instability

Welcome to the complementary web portal for our study characterizing chromosomal instability using copy number signatures.

Drews et al., Nature (2022)

Here you will find a collection of links to supporting material outside the main manuscript, as well as the opportunity to explore the signatures, their definitions, activities across the TCGA cohort and their association with common covariates.

Contact for collaboration

Please contact Florian Markowetz and Geoff Macintyre

Supplementary information

Code repositories

Version and license


The methods implemented in the code are the subject of the pending patent application GB 2114203.9

The source code is licensed under the Available Source License (ASL) and is available for non-commercial use only.

Major covariates

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